Successful Kidney Transplant From a Donor With Marfan Syndrome: A Case Report.

Marfan syndrome, a rare autosomal dominant connective tissue disorder caused by mutations in fibrillin-1, is primarily associated with cardiovascular complications such as aortic aneurysms and dissection. Despite the organ shortage crisis, kidneys from donors with Marfan syndrome are often rejected due to concerns about potential vascular complications. This case report presents the successful transplantation of a kidney from a 47-year-old male donor with Marfan syndrome into a 66-year-old female recipient with end-stage renal disease secondary to diabetic nephropathy. The donor had no prior history of aortic aneurysms, and peri-mortem imaging confirmed the absence of vascular complications. The transplantation was performed without complications. The recipient demonstrated excellent graft function postoperatively and at 17 months posttransplant with no evidence of vascular abnormalities. This case supports the consideration of kidneys from donors with Marfan syndrome to help reduce the organ shortage.