International journal of hygiene and environmental health · 2026
Prenatal ambient heat exposure and neurodevelopment: A scoping review of human and animal research.
СтатьяScoping ReviewНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Rhaman Amina, Russell Danielle J, Kardol Leaf R, Quintrell Ebony, Morgan Shannon, Maung Candra, Talukder Azmain, Gebremedhin Aster, Tan Stephanie, Radha Krishnan Ramya Padmavathy, Kelty Erin, Wyrwoll Caitlin
Аннотация
BACKGROUND: Ambient heat exposure during pregnancy is associated with adverse outcomes, and adverse neurodevelopmental outcomes are an emerging concern. This scoping review synthesises human and animal evidence on the association between prenatal ambient heat exposure and poor neurodevelopmental outcomes.
METHODS: A search was conducted across MEDLINE, Global Health, Web of Science, PsycINFO, and CINAHL. Studies up until May 2025, examining prenatal ambient heat exposure and neurodevelopmental outcomes such as congenital malformations and mental health conditions, were included. Two reviewers independently screened and extracted in duplicate using Covidence. Studies were categorised based on short-term or long-term outcomes.
RESULTS: The search yielded 8189 studies, with 58 meeting the inclusion criteria (17 human, 41 animal). Animal evidence was primarily based on rodents (n = 32) exposed to extreme heat that caused hyperthermia. Human studies were methodologically diverse, yielding inconsistent results. There was robust evidence to suggest an increased risk of central nervous system (CNS) malformations and a reduction in brain weight in animal studies. However, evidence from the small number of human studies was inconclusive. For long-term outcomes, such as mental health (n = 11), both human and animal studies were limited but generally reported adverse outcomes.
CONCLUSION: Overall, the evidence suggests a potential link between prenatal heat exposure, CNS malformations and altered brain size in animal models; however, the implications for humans remain uncertain. Human studies were scarce and inconsistent in their approaches. Future animal studies should employ realistic heat exposures to improve human applicability, and human studies should utilise consistent outcomes and exposure measures.
METHODS: A search was conducted across MEDLINE, Global Health, Web of Science, PsycINFO, and CINAHL. Studies up until May 2025, examining prenatal ambient heat exposure and neurodevelopmental outcomes such as congenital malformations and mental health conditions, were included. Two reviewers independently screened and extracted in duplicate using Covidence. Studies were categorised based on short-term or long-term outcomes.
RESULTS: The search yielded 8189 studies, with 58 meeting the inclusion criteria (17 human, 41 animal). Animal evidence was primarily based on rodents (n = 32) exposed to extreme heat that caused hyperthermia. Human studies were methodologically diverse, yielding inconsistent results. There was robust evidence to suggest an increased risk of central nervous system (CNS) malformations and a reduction in brain weight in animal studies. However, evidence from the small number of human studies was inconclusive. For long-term outcomes, such as mental health (n = 11), both human and animal studies were limited but generally reported adverse outcomes.
CONCLUSION: Overall, the evidence suggests a potential link between prenatal heat exposure, CNS malformations and altered brain size in animal models; however, the implications for humans remain uncertain. Human studies were scarce and inconsistent in their approaches. Future animal studies should employ realistic heat exposures to improve human applicability, and human studies should utilise consistent outcomes and exposure measures.