[Clinical analysis of 26 littoral cell angioma of the spleen cases].

The clinical data of 26 patients with littoral cell angioma (LCA) of the spleen admitted to the First Affiliated Hospital of Zhengzhou University from January 2013 to August 2025 were retrospectively analyzed. There were 14 males and 12 females, with a mean age of (39.4±17.7) years. Ten patients presented with abdominal symptoms, and 5 had concurrent malignancies in other organs. CT/MRI findings predominantly showed single or multiple slightly hypodense/hypointense nodules within the spleen, with mild to moderate heterogeneous enhancement in the arterial phase and persistent enhancement in the venous phase. Pathological examination revealed that tumor cells co-expressed vascular endothelial markers (CD31, CD34, ERG, etc.) and histiocytic markers (CD68, etc.), with a biphenotypic expression rate of 17/18. Among 5 cases preoperatively suspected as splenic metastases, 2 were confirmed by needle biopsy and 3 were pathologically verified after simultaneous surgical resection. Twenty-four patients underwent splenectomy. All patients were alive without LCA-related recurrence, with a median follow-up and progression-free survival time both of 71 months (range: 3-144 months). The current study indicates that preoperative contrast-enhanced CT and MRI are helpful in the diagnosis of LCA. Splenectomy is the first choice for LCA treatment, and the prognosis is favorable.