Outcome of prolapsed chorioamniotic membrane: relationship between the degree of herniation, infection, and pregnancy prolongation.

Our objective was to determine the outcome predictor of conservative bed rest therapy for prolapsed chorioamniotic membrane. We could perform tocolysis for 61 women, 41 of visible membrane (group A) and 20 of protruding membrane (group B). The duration of pregnancy prolongation and gestational age (in weeks) at delivery in group A were significantly larger than in group B ( p < 0.05). Outcome of neonates was also significantly different between two groups ( p < 0.05). In 37 women of group A (90%) and 10 of group B (50%; group D), signs of infection were negative throughout the admission to delivery with conservative therapy (white blood cell counts </= 13000/microL and CRP values </= 1.0 mg/dL). In group D, pregnancy was prolonged 23.9 days, which was significantly longer than in group B ( p < 0.05). This study suggests that pregnancy prolongation for prolapsed membrane with conservative therapy depends on the success of prophylactic treatment for infection.