Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2012
[Successful microdissection testicular sperm extraction in patients with nonmosaic Klinefelter syndrome: three cases report].
Клинический случайАннотация на английскомСтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Zhao Lian-ming, Jiang Hui, Hong Kai, Huang Jin, Tang Wen-hao, Mao Jia-ming, Qiao Jie, Liu Ping, Lian Ying, Ma Lu-lin
Аннотация
OBJECTIVE: To discuss the method for patients with nonmosaic Klinefelter syndrome (KS) to father children.
METHODS: Microdissection testicular sperm extraction (micro-TESE) was performed for three patients with nonmosaic KS in our hospital.
RESULTS: Three patients (their ranging from 23 years to 36 years), were diagnosed with azoospermia after several semen analyses. By palpation, their testis size was estimated about 3 mL,1 mL, and 4 mL, respectively. Follicle-stimulating hormone (FSH) was 37.2 IU/L, 42.2 IU/L, and 30.5 IU/L, respectively. Luteinizing hormone (LH) was 15.5 IU/L, 11.2 IU/L, and 10.1 IU/L, respectively. Testosterone was 1.2 nmol/L, 5.6 nmol/L, and 8.2 nmol/L, respectively. The volume of semen was 0.8 mL, 0.2 mL, and 0.5 mL, respectively. There was no sperm and fructose was positive. The transrectal B-bilateral showed vas deferens and seminal vesicles were not abnormal. And all the patients had a uniform 47, XXY karyotype. During the operation, normal formation sperms were found in two patients. They only underwent one-side micro-TESE. Active sperms were found after being cultured. The sperms were kept under cryopreservation. The other patient underwent two-side micro-TESE. No sperm was found during the operation. After the operation, a few deformity sperms were found during the second searching. No active sperm was found after being cultured. The sperm wasn't kept under cryopreservation.
CONCLUSION: Although patients with nonmosaic KS have small testis and decreased spermatogenesis, some of them can obtain sperms by micro-TESE instead of accepting artificial insemination by donors.
METHODS: Microdissection testicular sperm extraction (micro-TESE) was performed for three patients with nonmosaic KS in our hospital.
RESULTS: Three patients (their ranging from 23 years to 36 years), were diagnosed with azoospermia after several semen analyses. By palpation, their testis size was estimated about 3 mL,1 mL, and 4 mL, respectively. Follicle-stimulating hormone (FSH) was 37.2 IU/L, 42.2 IU/L, and 30.5 IU/L, respectively. Luteinizing hormone (LH) was 15.5 IU/L, 11.2 IU/L, and 10.1 IU/L, respectively. Testosterone was 1.2 nmol/L, 5.6 nmol/L, and 8.2 nmol/L, respectively. The volume of semen was 0.8 mL, 0.2 mL, and 0.5 mL, respectively. There was no sperm and fructose was positive. The transrectal B-bilateral showed vas deferens and seminal vesicles were not abnormal. And all the patients had a uniform 47, XXY karyotype. During the operation, normal formation sperms were found in two patients. They only underwent one-side micro-TESE. Active sperms were found after being cultured. The sperms were kept under cryopreservation. The other patient underwent two-side micro-TESE. No sperm was found during the operation. After the operation, a few deformity sperms were found during the second searching. No active sperm was found after being cultured. The sperm wasn't kept under cryopreservation.
CONCLUSION: Although patients with nonmosaic KS have small testis and decreased spermatogenesis, some of them can obtain sperms by micro-TESE instead of accepting artificial insemination by donors.