Nature communications · 2024
Antibody-dependent enhancement of toxicity of myotoxin II from Bothrops asper.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Sørensen Christoffer V, Fernández Julián, Adams Anna Christina, Wildenauer Helen H K, Schoffelen Sanne, Ledsgaard Line, Pucca Manuela B, Fiebig Michael, Cerni Felipe A, Tulika Tulika, Voldborg Bjørn G, Karatt-Vellatt Aneesh, Morth J Preben, Ljungars Anne, Grav Lise M, Lomonte Bruno, Laustsen Andreas H
Аннотация
Improved therapies are needed against snakebite envenoming, which kills and permanently disables thousands of people each year. Recently developed neutralizing monoclonal antibodies against several snake toxins have shown promise in preclinical rodent models. Here, we use phage display technology to discover a human monoclonal antibody and show that this antibody causes antibody-dependent enhancement of toxicity (ADET) of myotoxin II from the venomous pit viper, Bothrops asper, in a mouse model of envenoming that mimics a snakebite. While clinical ADET related to snake venom has not yet been reported in humans, this report of ADET of a toxin from the animal kingdom highlights the necessity of assessing even well-known antibody formats in representative preclinical models to evaluate their therapeutic utility against toxins or venoms. This is essential to avoid potential deleterious effects as exemplified in the present study.