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DOI 10.36849/jdd.9621

Медицинская библиотека · Journal of drugs in dermatology : JDD · 2026

Combined Use of Relabotulinum Toxin A and NASHA Gel Skinbooster for Rejuvenation of the Upper Third of the Face.

Iozzo Ivano, Belmontesi Magda, Gregorio Carlo Di, Clementoni Matteo Tretti, Antonucci Valentina Angela, Innocenti Alessandro

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Аннотация

BACKGROUND

Aging of the upper third of the face is characterized by dynamic forehead wrinkles and volume loss in the temporal region, resulting in a fatigued and aged appearance. Addressing both muscle hyperactivity and soft tissue atrophy is essential for effective rejuvenation.

OBJECTIVE

To evaluate a combined injectable treatment protocol using Relabotulinum Toxin A for frontalis muscle modulation and NASHA™-based gel skinbooster for temporal skin quality enhancement.

METHODS

Patients received intramuscular injections of Relabotulinum Toxin A targeting the frontalis muscle, followed by three monthly sessions of NASHA gel skinbooster injected subcutaneously into the temporal region using a blunt cannula technique. Dosages and injection points were individualized based on detailed anatomical and functional assessments.

RESULTS

Preliminary clinical evaluations indicate that the protocol is minimally invasive and well-tolerated, producing progressive aesthetic improvements lasting beyond six months. Patients reported enhanced skin tone, elasticity, hydration, and a natural-looking lift of the eyebrow tail. Improvements in psychological well-being and patient satisfaction were also observed.

CONCLUSION

This combined neuromodulation and skin quality improvement approach provides a comprehensive and synergistic strategy for upper facial rejuvenation. The ready-to-use liquid formulation of Relabotulinum Toxin A allows for precise application, rapid onset of results within 24-48 hours, and sustained improvement of forehead dynamic wrinkles for up to six months. The collagen-stimulating properties of NASHA gel deliver natural, long-lasting enhancement of the temporal region, contributing to high levels of patient satisfaction. &nbsp.

Для цитирования: Iozzo Ivano, Belmontesi Magda, Gregorio Carlo Di, Clementoni Matteo Tretti, Antonucci Valentina Angela, Innocenti Alessandro. Combined Use of Relabotulinum Toxin A and NASHA Gel Skinbooster for Rejuvenation of the Upper Third of the Face.. Journal of drugs in dermatology : JDD. 2026. DOI: 10.36849/jdd.9621.

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