[Tumor Cell and Brain Microenvironment Interactions in Non-small Cell Lung Cancer 
Brain Metastasis: Mechanisms and Emerging Insights].

Brain metastasis in non-small cell lung cancer (NSCLC) is shaped by continuous interactions between tumor cells and the brain-specific microenvironment. Vascular, glial and immune components contribute to intracranial colonization, immune escape and therapeutic resistance, while single-cell and spatial omics reveal heterogeneity in cellular states, communication networks and spatial niches. This review summarizes NSCLC brain metastasis and intracranial colonization, the brain metastatic microenvironment and tumor-microenvironment interactions, and discusses the heterogeneity revealed by single-cell and spatial omics and its potential relevance to therapeutic response and patient stratification.
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