Mental Health Challenges Among Transgender People: Exploring the Relationships Between Gender Dysphoria, Violence, and Severe Mental Health Outcomes Among Transgender Individuals Seeking Gender Affirming Care.

Transgender individuals face unique structural and interpersonal challenges that adversely affect their mental health. To investigate the association of gender dysphoria and experiences of sexual, physical, and emotional violence with severe depression, anxiety, and stress among transgender persons seeking gender-affirming care, this cross-sectional study involved 200 transgender individuals in a specialized health facility in Iran conducted between April and November 2021. Severe forms of depression, anxiety, and stress were the outcome variables measured using the Depression, Anxiety, and Stress Scale (DASS-21). Multivariable logistic regression analysis was conducted for data analysis. The prevalence of severe depression was 75%, severe anxiety was 92%, severe stress was 48%, and gender dysphoria was prevalent in 68% of the participants. Those who experienced sexual violence more frequently were associated with severe depression and severe stress. Additionally, those who experienced physical violence more frequently were associated with severe stress. Gender dysphoria was also significantly linked to elevated rates of depression, anxiety and stress. Transgender persons experiencing gender dysphoria and structural violence, and who are forced to seek gender-affirming care should also have access to gender-affirming mental health services that address both the psychological distress of gender incongruence and the impact of violence.