Nanomachines Based on Inner Ultrasonic Multiple Scattering for Ameliorating Renal Function.

Protecting cell/tissue disservice during acute kidney injury (AKI) was an important but still challenging goal. Here, we proposed a current-ultrasound convertion-propelled wireless positioning and tracking nanomachine in which Au covered one side of a PASP-PArg/BaTiO3 footplate (Au@PASP-PArg/BaTiO3, ASPB). These navigational nanomaches were used in the treatment of AKI to confirm a new technology and method for actively inhibiting kidney-trauma formation to enable highly efficient kidney-protection. ASPB possessed the high dielectric constant and piezoelectric properties, which acquired endogenous ultrasound-current and guided navigation under exogenous current excitement. Under the triggering of endogenous ultrasound, ASPB further gave rise to the unbalanced charges on its surface and underwent oxidation-reduction reactions with surrounding water, obtaining H2O2 and 1O2; meanwhile, ASPB could also decompose water to produce O2 under the inducement of endogenous ultrasound. Additionally, the attained H2O2 and 1O2 catalyzed polyarginine to discharge NO. Importantly, under accurate navigation, endogenous ultrasound-triggered gas sensor discharged NO/O2, and endogenous current could protect renal tissues from damage based on modulating MYDGF expressions, KCNQ1 functions, and TMAO targeted metabolomics. These current-ultrasound convertion-pushed navigational nanomaches clearly unveiled illustrious potential for promoting highly efficient kidney-function protection.