Intravascular large B-cell lymphoma with reversible central hypopituitarism.

We report the case of a woman in her late 60s who presented to our hospital with fever and general fatigue. Investigation revealed bicytopenia, splenomegaly and central hypothyroidism. Brain MRI revealed enlargement of the anterior pituitary lobe. A random skin biopsy demonstrated clusters of atypical lymphocytes within small vessels, leading to a diagnosis of intravascular large B-cell lymphoma (IVLBCL). The patient achieved complete remission following multi-agent chemotherapy and autologous peripheral blood stem cell transplantation, with normalisation of her endocrine function. This case represents a rare instance of IVLBCL presenting with hypopituitarism as a clinical manifestation.