Journal of occupational and environmental medicine · 2013
Risk of selected cancers due to occupational exposure to chlorinated solvents in a case-control study in Montreal.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Christensen Krista Yorita, Vizcaya David, Richardson Harriet, Lavoué Jérôme, Aronson Kristan, Siemiatycki Jack
Аннотация
OBJECTIVE: To evaluate the association between exposure to chlorinated solvents and cancer.
METHODS: We conducted a case-control study of occupational exposures and cancer in Montreal, Quebec, Canada, including 3730 cancer cases and 533 population controls. Occupational exposures were derived using a combination of subject-reported job history and expert assessment. We examined the associations between two chemical families and six chlorinated solvents with 11 sites of cancer.
RESULTS: The majority of the associations examined were null, although many were based on small numbers. We found two significantly elevated odds ratios (ORs), one between perchloroethylene and prostate cancer (OR = 4.3; 95% CI: 1.4 to 13) and another between trichloroethylene and melanoma (OR = 3.2; 95% CI: 1.0 to 9.9).
CONCLUSIONS: There was little evidence of associations between chlorinated solvents and cancer. Limited power precludes strong inferences about absence of risk. We raise hypotheses about two possible associations: perchloroethylene with prostate cancer and trichloroethylene with melanoma.
METHODS: We conducted a case-control study of occupational exposures and cancer in Montreal, Quebec, Canada, including 3730 cancer cases and 533 population controls. Occupational exposures were derived using a combination of subject-reported job history and expert assessment. We examined the associations between two chemical families and six chlorinated solvents with 11 sites of cancer.
RESULTS: The majority of the associations examined were null, although many were based on small numbers. We found two significantly elevated odds ratios (ORs), one between perchloroethylene and prostate cancer (OR = 4.3; 95% CI: 1.4 to 13) and another between trichloroethylene and melanoma (OR = 3.2; 95% CI: 1.0 to 9.9).
CONCLUSIONS: There was little evidence of associations between chlorinated solvents and cancer. Limited power precludes strong inferences about absence of risk. We raise hypotheses about two possible associations: perchloroethylene with prostate cancer and trichloroethylene with melanoma.