Медицинская библиотека · Zhonghua nan ke xue = National journal of andrology · 2006

[Effects of senility on inducible nitric oxide synthase expression and cell apoptosis in rat penis].

Liu Bo, Liu Ji-hong, Wang Tao, Xiao Heng-jun, Chen Jun, Luo Dong-xi, Ye Zhang-qun

Аннотация на английскомСтатьяПеревод в очереди

Аннотация

OBJECTIVES

To investigate the effect of senility on inducible nitric oxide synthase (iNOS) expression and apoptosis in rat penis.

METHODS

The rats were divided into three groups randomly: senescent, aged and young. Their penises were harvested to detect iNOS expression by immunohistochemistry and cell apoptosis rate by TUNEL, respectively.

RESULTS

iNOS expression were 0.24 +/- 0.03, 0.17 +/- 0.02, 0.12 +/- 0.03 (relative A) and cell apoptosis rate were (1.41 +/- 0.78)%, (0.94 +/- 0.43)% and (0.50 +/- 0.23 )%, respectively, in the tissues of three groups. The differences among three groups were considerable significance (P <0.05).

CONCLUSION

It maybe one of the mechanisms of erectile dysfunction in the aging male that senility causes the increase of iNOS expression and cell apoptosis.

Для цитирования: Liu Bo, Liu Ji-hong, Wang Tao, Xiao Heng-jun, Chen Jun, Luo Dong-xi, Ye Zhang-qun. [Effects of senility on inducible nitric oxide synthase expression and cell apoptosis in rat penis].. Zhonghua nan ke xue = National journal of andrology. 2006.

Предметные рубрики MeSH

Aging Animals Apoptosis In Situ Nick-End Labeling Male Nitric Oxide Synthase Type II Penis Random Allocation Rats Rats, Wistar

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