Sage open pediatrics · 2025
The Value of Netrin-1 and Neuron Specific Enolase biomarkers in neonates with Hypoxic İschemic Encephalopathy.
СтатьяНазвание и аннотация: Перевод в очереди
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Sobhi Ahmed, Al-Shokary Ashraf Hamed, Elmala Moustafa Kotb, El Faramawy Maha A, Ismail Nageh Shehata, Ibrahim Asmaa Obada, Kamal Naglaa M, Omar Deena Yasir Hussein, Eltayeb Ahmed Elrashed Elshaikh, Abdel Mageed Abeer Abdel Kader Elsayed, Elshorbagy Hatem Hamed, Abo Elela Ghada Mohamed, Eletr Omar Ahmed, Ali Rasha Aguib Hassan
Аннотация
OBJECTIVE: To investigate netrin-1 (NT-1) and neuron-specific enolase (NSE) in the umbilical cord as biomarkers in HIE stage II/III.
MATERIALS AND METHODS: We included 100 infants with HIE stage II/III and 100 controls. Cord samples were taken to determine the levels of NT-1 and NSE.
RESULTS: The HIE group showed significantly higher NT-1 (343.3 ± 100.6 pg/mL) and NSE (55.17 ± 13.4 ng/mL; P = .037, P = .007, respectively) than the control group, which had NT-1 (268.1 ± 79.3 pg/mL) and NSE (31.3 ± 19.5 ng/mL). The cut-off values for NT-1 and NSE were 289.3 pg/mL and 31.9 ng/mL, respectively. NT-1 had a sensitivity of 92%, a specificity of 100%, a positive predictive value (PPV) of 94%, and a negative predictive value (NPV) of 100%. The sensitivity, specificity, PPV, and NPV for NSE were all 100%.
CONCLUSION: NT-1 and NSE can be reliable biomarkers for predicting HIE stage II/III.
MATERIALS AND METHODS: We included 100 infants with HIE stage II/III and 100 controls. Cord samples were taken to determine the levels of NT-1 and NSE.
RESULTS: The HIE group showed significantly higher NT-1 (343.3 ± 100.6 pg/mL) and NSE (55.17 ± 13.4 ng/mL; P = .037, P = .007, respectively) than the control group, which had NT-1 (268.1 ± 79.3 pg/mL) and NSE (31.3 ± 19.5 ng/mL). The cut-off values for NT-1 and NSE were 289.3 pg/mL and 31.9 ng/mL, respectively. NT-1 had a sensitivity of 92%, a specificity of 100%, a positive predictive value (PPV) of 94%, and a negative predictive value (NPV) of 100%. The sensitivity, specificity, PPV, and NPV for NSE were all 100%.
CONCLUSION: NT-1 and NSE can be reliable biomarkers for predicting HIE stage II/III.