Combinatorial chemistry & high throughput screening · 2026
Exploring the Molecular Pathways of Tinospora cordifolia in the Management of Diabetic Foot Ulcers.
СтатьяНазвание и аннотация: Перевод в очереди
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Kumari Mamta, Sadhu Piyushkumar, Shah Niyati, Talele Chitrali, Saraogi Gaurav Kant, Sharma Shikha
Аннотация
INTRODUCTION: Medicinal plants are increasingly recognized as alternative and complementary therapies, particularly in India and other Asian countries. Tinospora cordifolia (Giloy/Guduchi) is a well-known medicinal plant with extensive therapeutic applications, including immune modulation, antidiabetic, anti-inflammatory, antioxidant, and antimicrobial effects. Given these properties, T. cordifolia shows promise for managing Diabetic Foot Ulcers (DFUs), a severe complication of diabetes associated with infection and the risk of amputation.
METHODS: This review compiles and critically analyzes the published literature on T. cordifolia, focusing on its phytochemical composition, pharmacological activities, and therapeutic relevance to diabetic foot ulcers. Data were gathered from PubMed, Scopus, Web of Science, and Google Scholar, including experimental, preclinical, and clinical studies describing its bioactive constituents and mechanisms related to immune regulation and wound healing.
RESULTS: Bioactive compounds such as alkaloids, diterpenoids, and polysaccharides derived from the stem, root, and whole plant exhibit significant immunomodulatory, anti-inflammatory, antioxidant, and antibacterial activities. These properties collectively support enhanced wound healing, infection control, and immune regulation, indicating the potential effectiveness of T. cordifolia in the treatment of DFU. Its favorable physiological compatibility and minimal side effects further strengthen its therapeutic value.
DISCUSSION: The multifaceted pharmacological actions of T. cordifolia align well with the complex pathophysiology of diabetic foot ulcers, which involves impaired immunity, chronic inflammation, oxidative stress, and microbial infection. The plant's immune-modulating and wound-healing effects suggest its usefulness as an adjunct to conventional DFU therapies. However, mechanistic insights and standardized clinical evidence remain limited.
CONCLUSION: Tinospora cordifolia represents a promising adjunctive therapeutic option for the management of diabetic foot ulcers. Future research should emphasize detailed biochemical mechanisms, synergistic effects with conventional drugs or other herbs, and well-designed clinical trials. Its incorporation into nutraceuticals and dietary supplements may further aid in chronic disease management and immune enhancement, bridging traditional knowledge with modern therapeutic strategies.
METHODS: This review compiles and critically analyzes the published literature on T. cordifolia, focusing on its phytochemical composition, pharmacological activities, and therapeutic relevance to diabetic foot ulcers. Data were gathered from PubMed, Scopus, Web of Science, and Google Scholar, including experimental, preclinical, and clinical studies describing its bioactive constituents and mechanisms related to immune regulation and wound healing.
RESULTS: Bioactive compounds such as alkaloids, diterpenoids, and polysaccharides derived from the stem, root, and whole plant exhibit significant immunomodulatory, anti-inflammatory, antioxidant, and antibacterial activities. These properties collectively support enhanced wound healing, infection control, and immune regulation, indicating the potential effectiveness of T. cordifolia in the treatment of DFU. Its favorable physiological compatibility and minimal side effects further strengthen its therapeutic value.
DISCUSSION: The multifaceted pharmacological actions of T. cordifolia align well with the complex pathophysiology of diabetic foot ulcers, which involves impaired immunity, chronic inflammation, oxidative stress, and microbial infection. The plant's immune-modulating and wound-healing effects suggest its usefulness as an adjunct to conventional DFU therapies. However, mechanistic insights and standardized clinical evidence remain limited.
CONCLUSION: Tinospora cordifolia represents a promising adjunctive therapeutic option for the management of diabetic foot ulcers. Future research should emphasize detailed biochemical mechanisms, synergistic effects with conventional drugs or other herbs, and well-designed clinical trials. Its incorporation into nutraceuticals and dietary supplements may further aid in chronic disease management and immune enhancement, bridging traditional knowledge with modern therapeutic strategies.