The Journal of antimicrobial chemotherapy · 2007
In vitro susceptibility of Madurella mycetomatis, prime agent of Madura foot, to tea tree oil and artemisinin.
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van de Sande Wendy W J, Fahal Ahmed H, Riley Thomas V, Verbrugh Henri, van Belkum Alex
Аннотация
OBJECTIVES: Eumycetoma caused by Madurella mycetomatis is treated with surgery and high doses of itraconazole and ketoconazole. These agents are toxic, and new therapies are required.
METHODS: MICs were determined for artemisinin and tea tree oil, two natural herbal compounds.
RESULTS: Artemisinin was not active against M. mycetomatis, but tea tree oil did inhibit its growth. Since tea tree oil's prime component easily penetrates the skin, tea tree oil could be a useful agent in the treatment of eumycetoma.
CONCLUSIONS: Tea tree oil is active in vitro against M. mycetomatis.
METHODS: MICs were determined for artemisinin and tea tree oil, two natural herbal compounds.
RESULTS: Artemisinin was not active against M. mycetomatis, but tea tree oil did inhibit its growth. Since tea tree oil's prime component easily penetrates the skin, tea tree oil could be a useful agent in the treatment of eumycetoma.
CONCLUSIONS: Tea tree oil is active in vitro against M. mycetomatis.