Identification risk factors for perinatal complications among pregnant women with pulmonary arterial hypertension.

BACKGROUND

The risk factors for perinatal complications in pregnant women with pulmonary arterial hypertension (PAH) remain controversial. This study aimed to explore the risk factors and constructed a prediction model for perinatal complications in pregnant women with PAH.

METHOD: A total of 116 pregnant women with PAH were retrospectively recruited from the Union Hospital affiliated with the Fujian Medical University between January 2016 and December 2016. The risk factors for perinatal complications were identified by using logistic regression model, while the predictive value of identified factors was assessed using the area under a receiver operating characteristic (ROC) curve.

RESULTS

Multivariate results indicated moderate PAH (OR: 15.38; 95% CI: 1.54-166.67; P = 0.020), and congenital heart disease (OR: 2.60; 95% CI: 1.25-5.41; p = 0.010) were associated with an increased risk of perinatal complications. A predictive model based on the aforementioned factors for perinatal complications in pregnant women with PAH was constructed, and the area under a ROC curve was 0.73 (95% CI: 0.60-0.86).

CONCLUSION

Perinatal complications in pregnant women with PAH could be affected by the severity of PAH and congenital heart disease and that the predictive value of the constructed model was moderate.