Advances in multi-omics and aging clock research for female reproductive health and aging.

With the global increase in life expectancy, the aging of the female reproductive system has become a critical area of focus due to its profound implications for overall health and quality of life. Advances in multiomics technologies, encompassing epigenetics, transcriptomics, proteomics, metabolomics, and microbiomics, have provided transformative insights into the complex biology of female reproductive health and aging. Computational models called aging clocks, based on these approaches, enable the precise assessment of biological age, identification of tissue-specific vulnerabilities, and elucidation of systemic aging patterns. While multi-omics and aging clock research in the female reproductive tract remains an evolving field, the growing availability of high-quality studies and resources offers promising opportunities to advance our understanding of reproductive aging and other significant issues in female reproductive health, such as infertility and pregnancy complications.