Veterinary medicine and science · 2025
Relationship between Urine Protein-To-Creatinine Ratio and Leukocyte Esterase in Canine Urine Samples.
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Liao Chen-Yin, Cheng Tsun-Li, Lai Cheng-Hung
Аннотация
BACKGROUND: The urine dipstick strip test is used for detecting urinary leukocytes and protein; however, factors like specific gravity, pH and infection may affect accuracy. Concerns exist regarding white blood cells interfering with the urine protein-to-creatinine (UP/C) ratio, a key test for proteinuria.
OBJECTIVES: This study aimed to determine whether the results of the leukocyte esterase test affect the UP/C ratio in canine urine samples.
METHODS: A total of 186 canine urine samples were collected. The dipstick strip leukocyte esterase test was used to classify the specimens into two groups: leukocyte strip-positive (+) and leukocyte strip-negative (-). The UP/C ratio was then measured for all samples employing the Catalyst One biochemical analyser.
RESULTS: The absolute value of the correlation coefficient between leukocyte strip status (±) and the UP/C ratio was 0.014 (p = 0.849), indicating no significant correlation. When applying the International Renal Interest Society (IRIS) grading criteria and setting the threshold for abnormal UP/C at ≥ 0.2, no significant correlation was found between leukocyte strip status and abnormal UP/C (p = 0.490). When categorising the UP/C ratio according to IRIS classification criteria, the absolute value of the correlation coefficient between leukocyte strip status and UP/C classification was 0.032 (p = 0.661), again showing no association. These findings suggest that a positive leukocyte esterase test does not interfere with the UP/C ratio.
CONCLUSIONS: The presence of a positive leukocyte esterase test does not affect the UP/C ratio in canine urine samples. Therefore, the UP/C ratio test can be performed regardless of the results of the leukocyte esterase test.
OBJECTIVES: This study aimed to determine whether the results of the leukocyte esterase test affect the UP/C ratio in canine urine samples.
METHODS: A total of 186 canine urine samples were collected. The dipstick strip leukocyte esterase test was used to classify the specimens into two groups: leukocyte strip-positive (+) and leukocyte strip-negative (-). The UP/C ratio was then measured for all samples employing the Catalyst One biochemical analyser.
RESULTS: The absolute value of the correlation coefficient between leukocyte strip status (±) and the UP/C ratio was 0.014 (p = 0.849), indicating no significant correlation. When applying the International Renal Interest Society (IRIS) grading criteria and setting the threshold for abnormal UP/C at ≥ 0.2, no significant correlation was found between leukocyte strip status and abnormal UP/C (p = 0.490). When categorising the UP/C ratio according to IRIS classification criteria, the absolute value of the correlation coefficient between leukocyte strip status and UP/C classification was 0.032 (p = 0.661), again showing no association. These findings suggest that a positive leukocyte esterase test does not interfere with the UP/C ratio.
CONCLUSIONS: The presence of a positive leukocyte esterase test does not affect the UP/C ratio in canine urine samples. Therefore, the UP/C ratio test can be performed regardless of the results of the leukocyte esterase test.