The European respiratory journal · 2026
Computed tomography total vessel count and vessel count percentages: associations with exercise capacity, symptoms and rapid FEV1 decline in COPD.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Singh Gaurav Veer, Asghar Huma, Collins Sophie É, Genkin Daniel, Hogg James C, Bourbeau Jean, Tan Wan C, Stickland Michael K, Kirby Miranda
Аннотация
BACKGROUND: Existing computed tomography (CT) vascular pruning measures rely on volumes, such as the proportion of blood volume in vessels with cross-sectional area (CSA) ≤5 mm2 or CSA ≤10 mm2/total blood vessel volume (BV5/TBV or BV10/TBV, respectively), but may underestimate vascular pruning due to blood redistribution to larger vessels in individuals with milder COPD. We aim to develop a novel CT vessel measure, the total vessel count (TVC), quantify small and combined small/intermediate vessel count percentages, and compare these measures with BV5/TBV and BV10/TBV in terms of associations with lung function and its decline. As a secondary aim, associations with exercise capacity and COPD symptoms will be investigated.
METHODS: CanCOLD (Canadian Cohort Obstructive Lung Disease) participants underwent CT imaging. BV5/TBV and BV10/TBV were generated using vessel segmentation. TVC and small (CSA ≤5 mm2, VC≤5/TVC) and combined small/intermediate (CSA ≤10 mm2, VC≤10/TVC) vessel count percentages were calculated. Fully adjusted regression models assessed associations with forced expiratory volume in 1 s (FEV1), FEV1/forced vital capacity (FVC), diffusing capacity of the lung for carbon monoxide (D LCO), accelerated FEV1 decline over 3 years, peak oxygen uptake (V̇ O2 peak), 6-min walk distance (6MWD) and Medical Research Council (MRC) dyspnoea scale.
RESULTS: 1254 CanCOLD participants were investigated. TVC, VC≤5/TVC and VC≤10/TVC were associated with FEV1/FVC (p<0.05), D LCO (p<0.05) and FEV1 decline (p<0.05); VC≤10/TVC was associated with V̇ O2 peak (p<0.05), and both VC≤5/TVC and VC≤10/TVC were associated with MRC (p<0.05). BV5/TBV and BV10/TBV were only associated with 6MWD (p<0.05) and MRC (p<0.05).
CONCLUSION: Pulmonary vessel count percent, a measure of vasculature narrowing/loss, is associated with lung function and its decline, reduced exercise capacity, and increased symptoms in COPD.
METHODS: CanCOLD (Canadian Cohort Obstructive Lung Disease) participants underwent CT imaging. BV5/TBV and BV10/TBV were generated using vessel segmentation. TVC and small (CSA ≤5 mm2, VC≤5/TVC) and combined small/intermediate (CSA ≤10 mm2, VC≤10/TVC) vessel count percentages were calculated. Fully adjusted regression models assessed associations with forced expiratory volume in 1 s (FEV1), FEV1/forced vital capacity (FVC), diffusing capacity of the lung for carbon monoxide (D LCO), accelerated FEV1 decline over 3 years, peak oxygen uptake (V̇ O2 peak), 6-min walk distance (6MWD) and Medical Research Council (MRC) dyspnoea scale.
RESULTS: 1254 CanCOLD participants were investigated. TVC, VC≤5/TVC and VC≤10/TVC were associated with FEV1/FVC (p<0.05), D LCO (p<0.05) and FEV1 decline (p<0.05); VC≤10/TVC was associated with V̇ O2 peak (p<0.05), and both VC≤5/TVC and VC≤10/TVC were associated with MRC (p<0.05). BV5/TBV and BV10/TBV were only associated with 6MWD (p<0.05) and MRC (p<0.05).
CONCLUSION: Pulmonary vessel count percent, a measure of vasculature narrowing/loss, is associated with lung function and its decline, reduced exercise capacity, and increased symptoms in COPD.