MedElevator
Войти в исследования Brain and behavior · 2026
Deep Brain Stimulation for Post-Stroke Movement Disorders of Various Etiologies: An Individual Participant Data (IPD) Meta-Analysis.
СтатьяМетаанализОбзорНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Kinfe Thomas, Pandey Sanjay, Regensburger Martin, Zaubitzer Maximilian, Schilling Achim, Brenner Steffen
Аннотация
BACKGROUND: Post-stroke movement disorders consisting of complex involuntary movement patterns with parkinsonism, dystonia, hemiballismus/hemichorea, and tremor represent a therapeutical challenge. Deep brain stimulation has been considered an effective treatment option, although it remains unclear which DBS targets should be approached.
METHODS: An individual participant data meta-analysis was conducted analyzing the efficacy (Burke Fahn Marsden Dystonia Rating Scale (BFM)-motor/-disability and the Fahn-Tolosa-Marín Scale for tremor (FTMTRS)) of pallidal (GPi) deep brain stimulation versus thalamic (VIM) versus GPi + VIM. PubMed, Embase, Cochrane Library, Ovid Medline, and Scopus were searched from 2000 to 2025. Additionally, correlation/regression analyses (age, duration of disease, stimulation parameters) were performed.
RESULTS: Sixteen studies including 32 patients (34.4% male; 65.6% female) were enrolled targeting the GPi (63.2%) versus VIM (23.6%) versus GPi/VIM-DBS (13.2%). Dystonia with tremor was found in 53%, dystonia with hemichorea/choreoathetosis in 50% (age at disease onset: 10 ± 18 years, age at DBS surgery: 37 ± 15 years, disease duration: 28 ± 19 years). GPi-DBS improved dystonia (BFM-motor: 6-12 months p < 0.005 and >12 months p = 0.038; BFM-disability 6-12 months p = 0.038) with no significant/relevant changes for VIM and GPi/VIM. No correlations were determined between DBS outcome and stimulation protocol and demographic characteristics. Adverse events occurred in 19%.
CONCLUSION: DBS is effective for treating post-stroke movement disorders of various etiologies. Given the heterogeneity, selection, and reporting bias, the published data is limited in providing high-quality evidence. Hence, the authors advocate a multifocal DBS approach along with trial stimulation determined under a rigorous study protocol.
METHODS: An individual participant data meta-analysis was conducted analyzing the efficacy (Burke Fahn Marsden Dystonia Rating Scale (BFM)-motor/-disability and the Fahn-Tolosa-Marín Scale for tremor (FTMTRS)) of pallidal (GPi) deep brain stimulation versus thalamic (VIM) versus GPi + VIM. PubMed, Embase, Cochrane Library, Ovid Medline, and Scopus were searched from 2000 to 2025. Additionally, correlation/regression analyses (age, duration of disease, stimulation parameters) were performed.
RESULTS: Sixteen studies including 32 patients (34.4% male; 65.6% female) were enrolled targeting the GPi (63.2%) versus VIM (23.6%) versus GPi/VIM-DBS (13.2%). Dystonia with tremor was found in 53%, dystonia with hemichorea/choreoathetosis in 50% (age at disease onset: 10 ± 18 years, age at DBS surgery: 37 ± 15 years, disease duration: 28 ± 19 years). GPi-DBS improved dystonia (BFM-motor: 6-12 months p < 0.005 and >12 months p = 0.038; BFM-disability 6-12 months p = 0.038) with no significant/relevant changes for VIM and GPi/VIM. No correlations were determined between DBS outcome and stimulation protocol and demographic characteristics. Adverse events occurred in 19%.
CONCLUSION: DBS is effective for treating post-stroke movement disorders of various etiologies. Given the heterogeneity, selection, and reporting bias, the published data is limited in providing high-quality evidence. Hence, the authors advocate a multifocal DBS approach along with trial stimulation determined under a rigorous study protocol.