IDCases · 2025
Graded isavuconazonium sulfate challenge in a patient with hypersensitivity to fluconazole.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
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Biagi Mark, Pierce Michael, Harney Wendy, Pereira-Rodrigues Otavio, Tsaras Geoffrey
Аннотация
Hypersensitivity reactions to triazole antifungals are uncommonly reported and cross-reactivity between these agents is poorly understood. We describe our experiences in a patient who previously developed a full body rash after receiving fluconazole who was initially successfully challenged and treated with isavuconazole without experiencing any adverse effects and was later separately re-challenged and treated successfully with a full-course of isavuconazole 8 months later. She received a third course of isavuconazole approximately 10 months after her second course, and developed rash, chest tightness, dyspnea, and facial flushing.