[Clinical study of tubal pregnancy treated with integrated traditional Chinese and Western medicine].

OBJECTIVE

To explore the therapeutic effect and the mechanism of tubal pregnancy (TP) treated with integrated traditional Chinese and Western medicine (TCM-WM).

METHODS

Seventy-eight patients suffering from TP were divided into two groups at random, 50 cases of treated group treated with the method of integrated Methotrexate (MTX) and Ectopic Pregnancy 2 (EP2) decoction, and the other 28 cases treated with MTX alone for control.

RESULTS

The nonsurgical method cure rate of the treated group (98.0%) was higher than that of the control group (75.0%, P < 0.01). The intrauterine pregnancy rate of the treated group was 80.0%, that of the control group was 42.9% (P < 0.01). The recurrent TP rate of the treated group (4.0%) was lower than that of the control group (14.2%, P < 0.01). The serum beta-HCG normalizing time of the treated group (25.0 +/- 7.8 days) was shorter than that of the control group (31.9 +/- 6.7 days, P < 0.05). The total disappearance time of TP mass was 1.2 +/- 0.7 months in the treated group, and in the control group was 5.6 +/- 3.7 months (P < 0.01). After treated by EP2 decoction for 4-8 weeks, the deformability of erythrocyte was increased, the aggregation of erythrocyte, the whole blood viscosity and the blood plasma viscosity were reduced.

CONCLUSIONS

The integrated method can effectively increase nonsurgical cure rate, tubal patency rate and intrauterine pregnancy rate, decrease recurrent TP rate in treating TP.