Journal of eating disorders · 2025
Exploring markers of feasibility for a pragmatic study of biomarkers in adolescents with eating disorders: steps towards a precision psychiatry approach.
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Norris Mark L, Power Krista A, Spettigue Wendy, Lavallée Niana, Gertler Madeline J, Livingston Dawson B H, Rodrigue Alexane F, Porter Janessa E, Pope Lori, Harrison Megan, Kanbur Nuray, Goldfield Gary S, Isserlin Leanna, Robinson Amy, Obeid Nicole
Аннотация
OBJECTIVE: To examine markers of feasibility for a pragmatic interdisciplinary multi-axial study of biomarkers in adolescents with eating disorders (EDs).
METHOD: The study included the collection of medical and clinical variables, psychometric measures, dietary logs, sensory and sleep assessments, and biological samples (i.e., blood and stool collection) for biomarker analyses. Adolescents between the ages of 11 to 17 diagnosed with a restrictive ED, along with control participants were enrolled between November 2021 to July 2024. Participants with EDs underwent concurrent treatment while enrolled in the study. Time points for low-weight patients included baseline, 4, 12, and 26 weeks, depending on the biological marker. Control subjects and patients over 90% treatment goal weight were assessed once. Feasibility was evaluated using clinical participant recruitment efficiency and uptake, adherence to the study protocol, rates of study completion, and self-reported ratings of acceptability.
RESULTS: In total, 100 participants with an ED, and 52 controls participated. We observed high rates of clinical participant enrolment, high adherence with most protocol collection procedures, modest dropout for longitudinal clinical participants (17% at 12 weeks), and positive feedback returned on surveys. We observed higher dropout at the 26-week timepoint (33%). Food log and sleep assessments were hindered by several contributing factors, resulting in completion rates of 31-70% and 40-87%.
DISCUSSION: Overall, results suggest acceptable feasibility for most variables assessed. Protocols requiring participation beyond 12 weeks, and utilizing dietary logs and sleep assessments, should be powered accordingly to account for lower completion rates. Further studies are needed to determine methods to optimize dietary and sleep assessments. This study provides valuable insights that can inform future precision psychiatry ED research strategies.
METHOD: The study included the collection of medical and clinical variables, psychometric measures, dietary logs, sensory and sleep assessments, and biological samples (i.e., blood and stool collection) for biomarker analyses. Adolescents between the ages of 11 to 17 diagnosed with a restrictive ED, along with control participants were enrolled between November 2021 to July 2024. Participants with EDs underwent concurrent treatment while enrolled in the study. Time points for low-weight patients included baseline, 4, 12, and 26 weeks, depending on the biological marker. Control subjects and patients over 90% treatment goal weight were assessed once. Feasibility was evaluated using clinical participant recruitment efficiency and uptake, adherence to the study protocol, rates of study completion, and self-reported ratings of acceptability.
RESULTS: In total, 100 participants with an ED, and 52 controls participated. We observed high rates of clinical participant enrolment, high adherence with most protocol collection procedures, modest dropout for longitudinal clinical participants (17% at 12 weeks), and positive feedback returned on surveys. We observed higher dropout at the 26-week timepoint (33%). Food log and sleep assessments were hindered by several contributing factors, resulting in completion rates of 31-70% and 40-87%.
DISCUSSION: Overall, results suggest acceptable feasibility for most variables assessed. Protocols requiring participation beyond 12 weeks, and utilizing dietary logs and sleep assessments, should be powered accordingly to account for lower completion rates. Further studies are needed to determine methods to optimize dietary and sleep assessments. This study provides valuable insights that can inform future precision psychiatry ED research strategies.