The Opioid Epidemic and Perinatal Health.

Opioid misuse, opioid use disorder (OUD), and opioid overdose continue to be significant contributors to perinatal morbidity and mortality, including in the postpartum period. Medications for OUD including methadone and buprenorphine reduce the risk of pregnancy-associated overdose and improve perinatal outcomes. Newer medications and medication formulations are currently being investigated to provide additional treatment options. Modifications to obstetric and pediatric management may be required to best support maternal, fetal, and neonatal outcomes. Harm reduction tools, including Narcan and fentanyl testing strip distribution, as well as sterile syringe exchanges, play a key role in reducing overdose mortality.