Fertility and sterility · 2005
Intrauterine instillation of trichloroacetic acid is effective for the treatment of dysfunctional uterine bleeding.
Клиническое исследованиеСтатьяРандомизированное исследованиеНазвание и аннотация: Перевод в очереди
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Kucuk Mustafa, Okman Tulay Kilic
Аннотация
OBJECTIVE: To evaluate the effectiveness of trichloroacetic acid (TCA) instillation into uterine cavity for the treatment of dysfunctional uterine bleeding (DUB).
DESIGN: Prospective clinical study.
SETTING: A university research hospital.
PATIENT(S): Ninety women participated who had dysfunctional uterine bleeding.
INTERVENTION(S): Ninety-five percent of TCA was instilled into uterine cavity for endometrial ablation in women with dysfunctional uterine bleeding who want conservative treatment. Participants in group 1 received only TCA; participants in group 2 received a single dose of gonadotropin-releasing hormone analogue 1 month before the procedure.
MAIN OUTCOME MEASURE(S): All participants underwent an evaluation that included cycle history, body mass index measurement, and transvaginal ultrasonography of pelvis, diagnostic hysteroscopy and endometrial biopsy.
RESULT(S): At the end of 12 months of the treatment, amenorrhea rates in group 1 and group 2 were 26.7% vs. 31.1%, with pooled amenorrhea, hypomenorrhea, and eumenorrhea rates of 95.6% vs. 97.8%, respectively. There was no significant difference between the groups vis-a-vis postprocedure results. More than 90% of women who have this procedure are satisfied with the results. There were no observed negative effects or related complications with this treatment.
CONCLUSION(S): An instillation of TCA into uterine cavity produces acceptable results and provides conservative management of DUB.
DESIGN: Prospective clinical study.
SETTING: A university research hospital.
PATIENT(S): Ninety women participated who had dysfunctional uterine bleeding.
INTERVENTION(S): Ninety-five percent of TCA was instilled into uterine cavity for endometrial ablation in women with dysfunctional uterine bleeding who want conservative treatment. Participants in group 1 received only TCA; participants in group 2 received a single dose of gonadotropin-releasing hormone analogue 1 month before the procedure.
MAIN OUTCOME MEASURE(S): All participants underwent an evaluation that included cycle history, body mass index measurement, and transvaginal ultrasonography of pelvis, diagnostic hysteroscopy and endometrial biopsy.
RESULT(S): At the end of 12 months of the treatment, amenorrhea rates in group 1 and group 2 were 26.7% vs. 31.1%, with pooled amenorrhea, hypomenorrhea, and eumenorrhea rates of 95.6% vs. 97.8%, respectively. There was no significant difference between the groups vis-a-vis postprocedure results. More than 90% of women who have this procedure are satisfied with the results. There were no observed negative effects or related complications with this treatment.
CONCLUSION(S): An instillation of TCA into uterine cavity produces acceptable results and provides conservative management of DUB.