Dose-response : a publication of International Hormesis Society · 2020
Study of Indicators for Early and Rapid Diagnosis of Radiation Injury Is the Most Important in Patients With Cancer During Radiotherapy.
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Liu Gang, Niu Li-Mei, Wang Li-Qin, Li Ye, Wu Xiao-Qin, Liu Yin-Yin, Zhang Rong
Аннотация
OBJECTIVE: To establish a complete technical solution for the radiation biological dose estimation, to enable prediction of individuals' response to radiotherapy (RT), and to control treatment dose for reduced irradiation injury and promote repair; and to evaluate the risk of radiation-induced late effects for patients undergoing external photon beam RT and provide the reliable dose-response relationships.
METHODS: Select 49 tumor patients using 60Co and linear accelerator for radiation therapy; initial radiation dose was 250 cGy. Chromosome aberration and blood count were analyzed before radiation therapy and 2 hours after the first day of RT.
RESULTS: Two hours after the first day of RT, peripheral blood cell count of lymphocytes of patients with cancer was significantly decreased (P < .01). The frequency of chromosome aberration was higher (P < .01).
CONCLUSION: High-dose radiation of the radiation therapy makes significant injuries to peripheral blood lymphocytes.
METHODS: Select 49 tumor patients using 60Co and linear accelerator for radiation therapy; initial radiation dose was 250 cGy. Chromosome aberration and blood count were analyzed before radiation therapy and 2 hours after the first day of RT.
RESULTS: Two hours after the first day of RT, peripheral blood cell count of lymphocytes of patients with cancer was significantly decreased (P < .01). The frequency of chromosome aberration was higher (P < .01).
CONCLUSION: High-dose radiation of the radiation therapy makes significant injuries to peripheral blood lymphocytes.