The Phytochemical Investigation, Thrombolytic, and Antioxidant Activity of Clerodendrum thomsoniae Balf.

Clerodendrum thomsoniae Balf. f. (Lamiaceae) is commonly known as the bleeding-heart vine or glory tree and traditionally used for treating blood-related disorders. This research investigated the phytochemical constituents, antioxidant capacity, and thrombolytic potential of leaf extracts. Among the extracts, the ethanol extract exhibited the highest total phenolic content, which correlated with its strong antioxidant activity demonstrated through multiple assays including DPPH, hydrogen peroxide, nitric oxide (NO) scavenging, and ferrous ion chelation. The petroleum ether extract showed notable thrombolytic activity by effectively lysing blood clots, achieving 34.52% clot lysis, which was significantly higher than the negative control (7.89%) but lower than the standard drug streptokinase (60.23%). Through GC-MS analysis, identified several bioactive compounds including sterols and fatty acids, which likely contribute these health benefits. These results suggest that C. thomsoniae leaves are a promising natural alternative for managing cardiovascular disorder and oxidative stress. Further in vivo studies and isolation of active compounds are essential.