Mycetoma.

Mycetoma is the most common deep mycosis in humans. It is a chronic, progressive, and destructive disease primarily caused by actinomycetes (98%). Mycetoma involves the skin and soft tissues, often bone, and occasionally the central nervous system, lungs, and other internal organs. It is found mainly in men working in the fields of countries located in tropical areas. Management with chemotherapy (trimethoprim-sulfamethoxazole, sulfonamides, amikacin, and others) is mandatory.