BJOG : an international journal of obstetrics and gynaecology · 2000
Fertility outcome following combined methotrexate treatment of unruptured extrauterine pregnancy.
СтатьяНазвание и аннотация: Перевод в очереди
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Debby A, Golan A, Sadan O, Zakut H, Glezerman M
Аннотация
OBJECTIVE: To assess the effectiveness of systemic treatment with methotrexate in combination with local injection for unruptured tubal pregnancy, and to evaluate reproductive function following treatment.
DESIGN: Prospective, open clinical study.
SETTING: University clinic.
POPULATION: Sixty-seven women with unruptured tubal pregnancy.
METHODS: Systemic methotrexate (intramuscular methotrexate 0.5 mg/kg for up to five days) in combination with local application of 12.5 mg methotrexate via laparoscopy.
MAIN OUTCOME MEASURES: The subsequent surgical intervention required and future fertility.
RESULTS: In 89.6% of women no further surgical intervention was required and 47 women (81%) experienced subsequently an intrauterine pregnancy. In 39 of 40 women who underwent hysterosalpingography following treatment, patency of the affected tube was observed.
CONCLUSIONS: Combined local and systemic methotrexate treatment for unruptured tubal pregnancy seems to be more effective than each therapeutic modality alone.
DESIGN: Prospective, open clinical study.
SETTING: University clinic.
POPULATION: Sixty-seven women with unruptured tubal pregnancy.
METHODS: Systemic methotrexate (intramuscular methotrexate 0.5 mg/kg for up to five days) in combination with local application of 12.5 mg methotrexate via laparoscopy.
MAIN OUTCOME MEASURES: The subsequent surgical intervention required and future fertility.
RESULTS: In 89.6% of women no further surgical intervention was required and 47 women (81%) experienced subsequently an intrauterine pregnancy. In 39 of 40 women who underwent hysterosalpingography following treatment, patency of the affected tube was observed.
CONCLUSIONS: Combined local and systemic methotrexate treatment for unruptured tubal pregnancy seems to be more effective than each therapeutic modality alone.