Journal of cutaneous medicine and surgery · 1998
Geneticists share the family jewels: how inbreeding has contributed to understanding hereditary skin disease.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Bale S J
Аннотация
BACKGROUND: Offspring resulting from consanguineous marriages have been important in advancing research in genodermatoses.
OBJECTIVE: The concepts of consanguinity and inbreeding are reviewed and their contributions to research in hereditary skin diseases explained.
METHODS: Examples are given in which inbred individuals with hereditary skin disease have increased our knowledge of skin disease genetics.
RESULTS: An enhanced understanding of the genetics of xeroderma pigmentosum, lamellar ichthyosis, and Werner's syndrome, among others, has arisen from the observation of populations and families in which inbreeding has occurred.
CONCLUSION: Populations practicing inbreeding and consanguineous marriages in generally outbred populations have provided important observations for determining the inheritance pattern of several genodermatoses and for identifying the responsible genes.
OBJECTIVE: The concepts of consanguinity and inbreeding are reviewed and their contributions to research in hereditary skin diseases explained.
METHODS: Examples are given in which inbred individuals with hereditary skin disease have increased our knowledge of skin disease genetics.
RESULTS: An enhanced understanding of the genetics of xeroderma pigmentosum, lamellar ichthyosis, and Werner's syndrome, among others, has arisen from the observation of populations and families in which inbreeding has occurred.
CONCLUSION: Populations practicing inbreeding and consanguineous marriages in generally outbred populations have provided important observations for determining the inheritance pattern of several genodermatoses and for identifying the responsible genes.