Journal of orthopaedic trauma · 2004
Head injury-associated bone fractures induce bacterial translocation: an experimental study.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Oztuna Volkan, Ersöz Gülden, Ayan Irfan, Eskandari Metin M, Uğuz Kayhan, Kuyurtar Fehmi
Аннотация
OBJECTIVES: To determine whether long bone fractures cause bacterial translocation and to investigate the effect of concomitant head trauma on this process.
DESIGN: An in vivo animal model.
SETTING: Animal Laboratory, University of Mersin School of Medicine, Mersin, Turkey.
SUBJECTS: Male Sprague-Dawley rats (n = 60).
INTERVENTION: Sixty male Sprague-Dawley rats were divided into five groups: (1). anesthesia only (control group, n = 12); (2). anesthesia and tibia fracture (n = 12); (3). anesthesia, tibia fracture, and femur fracture (n = 12); (4). anesthesia, tibia fracture, femur fracture, and moderate head trauma (n = 12); and (5). moderate head trauma only (n = 12). After 24 hours, mesenteric lymph nodes, liver, spleen, ileum, and systemic blood samples were quantitatively cultured for aerobic organisms.
MAIN OUTCOME MEASUREMENTS: Colony-forming unit per gram for bacteria count.
RESULTS: The incidence of bacterial translocation was higher in groups that had fractures (4/12 in group 2; 5/12 in group 3) than in the control group (2/12); however, this did not reach statistical significance. There was a significant increase in the number of subjects with bacterial translocation in group 4 (9/12) compared with the control group and group 5 (3/12) (P = 0.0123, P = 0.0391).
CONCLUSIONS: Multiple fractures of long bones associated with head injury promote bacterial translocation.
DESIGN: An in vivo animal model.
SETTING: Animal Laboratory, University of Mersin School of Medicine, Mersin, Turkey.
SUBJECTS: Male Sprague-Dawley rats (n = 60).
INTERVENTION: Sixty male Sprague-Dawley rats were divided into five groups: (1). anesthesia only (control group, n = 12); (2). anesthesia and tibia fracture (n = 12); (3). anesthesia, tibia fracture, and femur fracture (n = 12); (4). anesthesia, tibia fracture, femur fracture, and moderate head trauma (n = 12); and (5). moderate head trauma only (n = 12). After 24 hours, mesenteric lymph nodes, liver, spleen, ileum, and systemic blood samples were quantitatively cultured for aerobic organisms.
MAIN OUTCOME MEASUREMENTS: Colony-forming unit per gram for bacteria count.
RESULTS: The incidence of bacterial translocation was higher in groups that had fractures (4/12 in group 2; 5/12 in group 3) than in the control group (2/12); however, this did not reach statistical significance. There was a significant increase in the number of subjects with bacterial translocation in group 4 (9/12) compared with the control group and group 5 (3/12) (P = 0.0123, P = 0.0391).
CONCLUSIONS: Multiple fractures of long bones associated with head injury promote bacterial translocation.