The effect of natrium hyaluronate applied locally for pelviureteral anastomoses.

OBJECTIVES

This study aimed to investigate the effect of natrium hyaluronate (NH) on fibrous tissue formation and wound healing in experimental pelviureteral anastomosis (PUA).

MATERIALS AND

METHODS

Eighteen rabbits were divided equally into three groups: surgical (S), sham (Sh), and NH. A 1-cm length of the ureteropelvic segment was resected through a laparotomy incision and then anastomosis was performed. The rabbits were injected with saline (Sh group) and NH (NH group) into anastomoses lines after the surgical procedure. The S group did not receive any medication during their procedure. Intravenous pyelography was carried out on postoperative day 21. The rabbits were sacrificed and dissected under a dissecting microscope and examined for acute inflammation (AI), chronic inflammation (CI), granulation tissue amount (GTA), granulation tissue fibroblast maturation (GTFM), collagen deposition (CD), neovascularization (N), re-epithelialization (R), and peripheral tissue reaction (PTR) in the anastomosis lines 3 weeks later.

MAIN FINDINGS: There were no significant differences in the GTFM scores in the S group compared with those in the NH group. In the NH group, N scores were higher than they were in the S group. Re-epithelialization in the NH group was higher than it was in the S group.

PRINCIPLE

CONCLUSIONS

NH did not decrease fibrosis, but increased important parameters in wound healing such as neovascularization and re-epithelialization in an experimental model of PUA in rabbits.