Setting research priorities to improve global newborn health and prevent stillbirths by 2025.
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Yoshida Sachiyo, Martines José, Lawn Joy E, Wall Stephen, Souza Joăo Paulo, Rudan Igor, Cousens Simon, neonatal health research priority setting group, Aaby Peter, Adam Ishag, Adhikari Ramesh Kant, Ambalavanan Namasivayam, Arifeen Shams Ei, Aryal Dhana Raj, Asiruddin Sk, Baqui Abdullah, Barros Aluisio Jd, Benn Christine S, Bhandari Vineet, Bhatnagar Shinjini, Bhattacharya Sohinee, Bhutta Zulfiqar A, Black Robert E, Blencowe Hannah, Bose Carl, Brown Justin, Bührer Christoph, Carlo Wally, Cecatti Jose Guilherme, Cheung Po-Yin, Clark Robert, Colbourn Tim, Conde-Agudelo Agustin, Corbett Erica, Czeizel Andrew E, Das Abhik, Day Louise Tina, Deal Carolyn, Deorari Ashok, Dilmen Uğur, English Mike, Engmann Cyril, Esamai Fabian, Fall Caroline, Ferriero Donna M, Gisore Peter, Hazir Tabish, Higgins Rosemary D, Homer Caroline Se, Hoque D E, Irgens Lorentz, Islam M T, de Graft-Johnson Joseph, Joshua Martias Alice, Keenan William, Khatoon Soofia, Kieler Helle, Kramer Michael S, Lackritz Eve M, Lavender Tina, Lawintono Laurensia, Luhanga Richard, Marsh David, McMillan Douglas, McNamara Patrick J, Mol Ben Willem J, Molyneux Elizabeth, Mukasa G K, Mutabazi Miriam, Nacul Luis Carlos, Nakakeeto Margaret, Narayanan Indira, Olusanya Bolajoko, Osrin David, Paul Vinod, Poets Christian, Reddy Uma M, Santosham Mathuram, Sayed Rubayet, Schlabritz-Loutsevitch Natalia E, Singhal Nalini, Smith Mary Alice, Smith Peter G, Soofi Sajid, Spong Catherine Y, Sultana Shahin, Tshefu Antoinette, van Bel Frank, Gray Lauren Vestewig, Waiswa Peter, Wang Wei, Williams Sarah LA, Wright Linda, Zaidi Anita, Zhang Yanfeng, Zhong Nanbert, Zuniga Isabel, Bahl Rajiv
Аннотация
METHODS: We used adapted Child Health and Nutrition Research Initiative (CHNRI) methods for this prioritization exercise. We identified and approached the 200 most productive researchers and 400 program experts, and 132 of them submitted research questions online. These were collated into a set of 205 research questions, sent for scoring to the 600 identified experts, and were assessed and scored by 91 experts.
RESULTS: Nine out of top ten identified priorities were in the domain of research on improving delivery of known interventions, with simplified neonatal resuscitation program and clinical algorithms and improved skills of community health workers leading the list. The top 10 priorities in the domain of development were led by ideas on improved Kangaroo Mother Care at community level, how to improve the accuracy of diagnosis by community health workers, and perinatal audits. The 10 leading priorities for discovery research focused on stable surfactant with novel modes of administration for preterm babies, ability to diagnose fetal distress and novel tocolytic agents to delay or stop preterm labour.
CONCLUSION: These findings will assist both donors and researchers in supporting and conducting research to close the knowledge gaps for reducing neonatal mortality, morbidity and long term impairment. WHO, SNL and other partners will work to generate interest among key national stakeholders, governments, NGOs, and research institutes in these priorities, while encouraging research funders to support them. We will track research funding, relevant requests for proposals and trial registers to monitor if the priorities identified by this exercise are being addressed.