Residual pesticides in grape leaves (Vitis vinifera L.) on the Egyptian market and human health risk.

A QuEChERS method, followed by GC-MS/MS and LC-MS/MS was used for determining more than 400 pesticide residues in grape leaves collected from the Egyptian markets during the 2021 summer season. Seventy-eight samples contained 36 pesticide residues of different chemical groups above the EU-MRLs. Fungicides were the most frequently detected pesticides (59%), followed by insecticides (35%) and herbicides (5%).Hazard Quotients and Hazard Indexes were calculated where the results showed that both do not pose any health risk to consumers. Furthermore, cumulative risk assessment parameters (cHI) according to pesticide chemical group were calculated, resulting in 0.06, 0.09, 0.20, 0.28, 0.7 and 1.1% for strobin, organophosphorus, neonicotinoid, pyrethroid, benzimidazole and azole compounds, respectively. Fungicides were the major contributors to cHI, above insecticides by a factor of 2.7. Hence, there is a need for continuous survey and monitoring to protects consumers from exposure to unauthorized substances such as carbendazim, benomyl and profenofos.