Mesoporous silica derivatives in random optical fields.

In this study, we demonstrate label-free optical differentiation and motion hindrance of pristine MCM-41 and surface-modified MCM-41GA using random optical fields, also known as speckle tweezers (STs), within a microfluidic environment. MCM-41 (SBET = 800 m2 g-1, pore diameter = 2.0 nm, ζ = -30 mV) and MCM-41GA (SBET = 450 m2 g-1, pore diameter = 1.8 nm, ζ = 4 mV) are synthesized and structurally characterized by XRD, NMR, SEM, TGA, elemental analysis, and N2 sorption. Quantitative trajectory analysis reveals that illumination with a random optical field suppresses particle motility in both materials. For MCM-41, the mean velocity decreases from 8.9 to 8.0 μms-1 (Welch's p value ≈ 2.2 × 10-2), while for MCM-41GA, the mean velocity decreases from 4.4 to 3.6 μms-1 (Welch's p value ≈ 8 × 10-3). Overall, ST induces a consistent reduction in the mean particle velocity and a marked increase in the immobility, enabling optically driven, physicochemical-dependent spatial segregation of mesoporous silica particles within microfluidic chips.