Effect of H2S on Secretory Activity of Perivascular Adipose Tissue in Metabolic Syndrome.

We studied the effect of gaseous transmitter H2S on the cytokine-producing activity of perivascular adipose tissue in rats with metabolic syndrome modeled by high-fat high-carbohydrate diet for 12 weeks. It was shown that the serum concentration of H2S and the level of H2S biosynthesis enzyme (CSE) were decreased in animals with metabolic syndrome. The secretory activity of perivascular adipose tissue cellular elements after high-fat high-carbohydrate diet is characterized by increased synthesis of proinflammatory cytokines (IL-6, TNFα, MCP-1) and decreased production of anti-inflammatory IL-10. It was found that exogenous H2S donor (NaHS, 100 μM) shifted the balance of cytokines secreted by the perivascular adipose tissue by reducing the concentration of proinflammatory mediators, thereby exerting an anti-inflammatory effect on the perivascular adipose tissue.