Pyridine-N-oxide-Catalyzed N-Acylative Kinetic Resolution of Sulfoximines.

An efficient asymmetric N-acylative kinetic resolution of sulfoximines using chiral 4-arylpyridine-N-oxide as the catalyst was reported. Using 3,5-bis(trifluoromethyl)benzoyl chloride as the acyl transfer agent, both the recovered sulfoximines and the N-acylative sulfoximines exhibited good to excellent results, with s factors of up to 320.