Drug and alcohol dependence · 2020
Liver injury associated with kratom, a popular opioid-like product: Experience from the U.S. drug induced liver injury network and a review of the literature.
СтатьяПоддержка NIH: внешняя программаОбзорНазвание и аннотация: Перевод в очереди
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Ahmad Jawad, Odin Joseph A, Hayashi Paul H, Fontana Robert J, Conjeevaram Hari, Avula Bharathi, Khan Ikhlas A, Barnhart Huiman, Vuppalanchi Raj, Navarro Victor J, Drug-Induced Liver Injury Network
Аннотация
BACKGROUND: Kratom is a botanical product used as an opium substitute with abuse potential.
METHODS: Assessment of suspected cases of kratom-induced liver injury in a prospective US cohort.
RESULTS: Eleven cases of liver injury attributed to kratom were identified with a recent increase. The majority were male with median age 40 years. All were symptomatic and developed jaundice with a median latency of 14 days. The liver injury pattern was variable, most required hospitalization and all eventually recovered. Biochemical analysis revealed active kratom ingredients.
CONCLUSION: Kratom can cause severe liver injury with jaundice.
METHODS: Assessment of suspected cases of kratom-induced liver injury in a prospective US cohort.
RESULTS: Eleven cases of liver injury attributed to kratom were identified with a recent increase. The majority were male with median age 40 years. All were symptomatic and developed jaundice with a median latency of 14 days. The liver injury pattern was variable, most required hospitalization and all eventually recovered. Biochemical analysis revealed active kratom ingredients.
CONCLUSION: Kratom can cause severe liver injury with jaundice.