Pregnancy outcome in carriers of fragile X.

OBJECTIVE

To evaluate pregnancy outcome in women who are carriers of fragile X.

DESIGN

Cross-sectional case-control study.

SETTING

Department of Obstetrics and Gynaecology, Kuopio University Hospital, Finland.

SAMPLE: Sixty-three singleton pregnancies in carriers of fragile X who were referred for genetic counselling and prenatal diagnosis to Kuopio University Hospital.

METHODS

Logistic regression analysis was used to compare pregnancy outcome in women who are fragile X carrier with outcome of the general obstetric population.

RESULTS

Carriers of fragile X often experienced more bleeding in late pregnancy than did the reference group. Otherwise, the course and outcome of pregnancy were comparable in both groups.

CONCLUSION

Pregnancy outcome in women who are carriers of fragile X is favourable. There is no need to initiate special fetal monitoring because of the fragile X status of the woman.