Revista brasileira de enfermagem · 2026
Ivermectin in Acute Renal Injury Induced by Ischemia-Reperfusion: An Experimental Study in Wistar Rats.
СтатьяНазвание и аннотация: Перевод в очереди
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Budini Raphael Cuencas, Barbosa Dulce Aparecida, Oliveira Iris Gabriela Piazentin de, Silva Ricardo Dos Santos, Sousa Adriana Almeida de, Thibes Milene Subtil Ormanji, Fonseca Cassiane Dezoti da
Аннотация
OBJECTIVES: to assess the effect of ivermectin in an experimental model of ischemia-reperfusion as a risk factor.
METHODS: twenty adult male Wistar rats were randomized into the following groups: Sham: surgical simulation without clamping of the renal pedicles; ischemia: clamping of the renal pedicles for 30 minutes; Sham + ivermectin: 10 mg/kg of ivermectin, orally, once daily for five days; and Ischemia + ivermectin. Physiological parameters such as body weight, water and food intake, renal function (creatinine clearance), and oxidative profile (urinary peroxides and thiobarbituric acid reactive substances) were assessed.
RESULTS: an increase in kidney-to-body weight ratio, serum creatinine, and oxidative stress was observed in animals treated with ivermectin (p<0.05).
CONCLUSIONS: the use of ivermectin, associated with the ischemia-reperfusion risk factor, demonstrated nephrotoxic action in Wistar rats, evidenced by impaired renal function and increased oxidative stress.
METHODS: twenty adult male Wistar rats were randomized into the following groups: Sham: surgical simulation without clamping of the renal pedicles; ischemia: clamping of the renal pedicles for 30 minutes; Sham + ivermectin: 10 mg/kg of ivermectin, orally, once daily for five days; and Ischemia + ivermectin. Physiological parameters such as body weight, water and food intake, renal function (creatinine clearance), and oxidative profile (urinary peroxides and thiobarbituric acid reactive substances) were assessed.
RESULTS: an increase in kidney-to-body weight ratio, serum creatinine, and oxidative stress was observed in animals treated with ivermectin (p<0.05).
CONCLUSIONS: the use of ivermectin, associated with the ischemia-reperfusion risk factor, demonstrated nephrotoxic action in Wistar rats, evidenced by impaired renal function and increased oxidative stress.