Ivermectin in Acute Renal Injury Induced by Ischemia-Reperfusion: An Experimental Study in Wistar Rats.

OBJECTIVES

to assess the effect of ivermectin in an experimental model of ischemia-reperfusion as a risk factor.

METHODS

twenty adult male Wistar rats were randomized into the following groups: Sham: surgical simulation without clamping of the renal pedicles; ischemia: clamping of the renal pedicles for 30 minutes; Sham + ivermectin: 10 mg/kg of ivermectin, orally, once daily for five days; and Ischemia + ivermectin. Physiological parameters such as body weight, water and food intake, renal function (creatinine clearance), and oxidative profile (urinary peroxides and thiobarbituric acid reactive substances) were assessed.

RESULTS

an increase in kidney-to-body weight ratio, serum creatinine, and oxidative stress was observed in animals treated with ivermectin (p<0.05).

CONCLUSIONS

the use of ivermectin, associated with the ischemia-reperfusion risk factor, demonstrated nephrotoxic action in Wistar rats, evidenced by impaired renal function and increased oxidative stress.