High-resolution simulations reveal positive global warming feedback from Pacific low clouds.

Uncertainty in marine low-level cloud feedbacks limits accurate climate projections. Using 7083 high-resolution simulations of tropical Pacific low clouds, we separated the impacts of sea surface warming from direct carbon dioxide (CO2) effects. Surface warming alone drives a positive low-cloud feedback of [Formula: see text]. While this changes little with doubled CO2, the total cloud radiative response strengthens markedly to [Formula: see text] under quadrupled CO2, revealing a strong nonlinear interaction. Surface warming alone modifies the boundary layer through increased inversion strength and weakened subsidence, which buffers clouds by promoting higher liquid water content while cloud fraction decreases. Rapid adjustments to high CO2 concentrations counteract this protective cloud thickening. Consequently, a pronounced reduction in cloud fraction is no longer offset by an increase in cloud brightness, markedly strengthening the total radiative response under quadrupled CO2. Ultimately, our results suggest that climate sensitivity is more state-dependent than often assumed.