bioRxiv : the preprint server for biology · 2025
Impact of > 24 h sustained wakefulness and subsequent recovery sleep on time-dependent changes in microRNA factors of individuals with post-acute phase mild traumatic brain injury.
СтатьяПрепринтНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Brager Allison, Edwards Katie, Pattinson Cassie, Peyer J, Gill Jessica
Аннотация
INTRODUCTION: The purpose of the present study was to determine whether mild traumatic brain injury (mTBI+) results in latent changes in microRNA expression profiles across an episode of total sleep deprivation (TSD).
METHODS: Seven previously concussed (mTBI+) adults (24.5 ± 5.3 y.o.) and 6 non-concussed control adults (mTBI-; 24.8 ± 1.6 y.o.) underwent 24 h TSD (T2) preceded by 8 h baseline sleep (T1; BSL) and followed by 8 h recovery (T3; REC) sleep. Salivary microRNA expression was assessed across the entire study.
RESULTS: Subjects (mTBI+ and mTBI-) had differential expression of salivary microRNA targets across TSD. mTBI+ subjects had greater change to microRNA expression profiles compared to mTBI- subjects between T1 and T3.
DISCUSSION: Although there is some evidence that TSD may unmask latent changes in gene expression in mTBI+ subjects, a definitive conclusion was precluded by differences in baseline sleep in mTBI+ (vs. mTBI-) subjects measured through polysomnography (not shown). However, this study is unique in that the mTBI+ subjects were exposed to a sleep deprivation challenge very shortly after medical clearance from mTBI demonstrating lingering neurobiological impacts of mTBI.
METHODS: Seven previously concussed (mTBI+) adults (24.5 ± 5.3 y.o.) and 6 non-concussed control adults (mTBI-; 24.8 ± 1.6 y.o.) underwent 24 h TSD (T2) preceded by 8 h baseline sleep (T1; BSL) and followed by 8 h recovery (T3; REC) sleep. Salivary microRNA expression was assessed across the entire study.
RESULTS: Subjects (mTBI+ and mTBI-) had differential expression of salivary microRNA targets across TSD. mTBI+ subjects had greater change to microRNA expression profiles compared to mTBI- subjects between T1 and T3.
DISCUSSION: Although there is some evidence that TSD may unmask latent changes in gene expression in mTBI+ subjects, a definitive conclusion was precluded by differences in baseline sleep in mTBI+ (vs. mTBI-) subjects measured through polysomnography (not shown). However, this study is unique in that the mTBI+ subjects were exposed to a sleep deprivation challenge very shortly after medical clearance from mTBI demonstrating lingering neurobiological impacts of mTBI.