Successful Management of a Parapharyngeal Abscess With Pharyngeal Perforation and Internal Jugular Vein Thrombosis in a Patient With a History of Lymphoma.

Deep neck space infections (DNSIs) are rare but potentially life-threatening conditions due to their rapid progression and proximity to vital structures. The conventional management of this condition is multidisciplinary, requiring broad-spectrum antibiotic therapy and surgical intervention when deemed necessary. The prognosis of DNSIs relies on the immune status of its host, severity, and anatomical location, with high and fluctuating mortality rates if inadequately managed. A timely intervention prevents the progression to higher-risk complications, including Lemierre syndrome, mediastinitis, and respiratory failure. The authors herein present the case of a complicated parapharyngeal abscess requiring a multidisciplinary medical and surgical approach via abscess drainage, pharyngeal defect repair, and muscle flap reinforcement. This case highlights the importance of early recognition, surgical expertise, and tailored postoperative care in the management of complex DNSIs.