Orvosi hetilap · 2007
[Complex analysis of prognostic factors in chronic lymphocytic leukemia].
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Kajtár Béla, Jáksó Pál, Kereskai László, Lacza Agnes, Méhes Gábor, Bodnár Mária Anna, Dombi J Péter, Gasztonyi Zoltán, Egyed Miklós, Iványi János László, Kovács Gábor, Marton Eva, Palaczki Aranka, Petz Sándor, Tóth Péter, Sziládi Erzsébet, Losonczy Hajna, Pajor László
Аннотация
INTRODUCTION: Many new prognostic factors established in recent years in chronic lymphocytic leukemia. May help predicting survival.
AIMS: The goal of the present study was to determine the frequency and the correlation of these novel prognostic factors in samples of 419 leukemia patients.
METHODS: The mutation status of the IgH gene was evaluated in 160 cases.
RESULTS: In 62% of cases, non-mutated IgH gene was found, the heavy chain family usage was different in mutated and non-mutated cases. The CD38 expression demonstrated 78% concordance with the mutation status, the ZAP-70 expression failed to show any correlation. Cytogenetic abnormalities were seen in 76% of cases, the most frequent were del(13q) (57%), trisomy 12 (15%), del(11q) (12%) and del(17p) (6%). 95% of cases with del(11q) harbored non-mutated, 74% of cases with del(13q) as the sole anomaly demonstrated mutated IgH genes.
CONCLUSIONS: The parameters analysed are not independent of each other, utilization of them in the clinical routine needs careful planning.
AIMS: The goal of the present study was to determine the frequency and the correlation of these novel prognostic factors in samples of 419 leukemia patients.
METHODS: The mutation status of the IgH gene was evaluated in 160 cases.
RESULTS: In 62% of cases, non-mutated IgH gene was found, the heavy chain family usage was different in mutated and non-mutated cases. The CD38 expression demonstrated 78% concordance with the mutation status, the ZAP-70 expression failed to show any correlation. Cytogenetic abnormalities were seen in 76% of cases, the most frequent were del(13q) (57%), trisomy 12 (15%), del(11q) (12%) and del(17p) (6%). 95% of cases with del(11q) harbored non-mutated, 74% of cases with del(13q) as the sole anomaly demonstrated mutated IgH genes.
CONCLUSIONS: The parameters analysed are not independent of each other, utilization of them in the clinical routine needs careful planning.
Предметные рубрики MeSH
ADP-ribosyl Cyclase 1AgedChromosomes, Human, Pair 11Chromosomes, Human, Pair 13Chromosomes, Human, Pair 17DNA, NeoplasmFemaleFlow CytometryGene DeletionGene RearrangementGenes, Immunoglobulin Heavy ChainHumansIn Situ Hybridization, FluorescenceKaryotypingLeukemia, Lymphocytic, Chronic, B-CellMaleMiddle AgedMutationPredictive Value of TestsPrognosisSequence Analysis, DNASurvival AnalysisTrisomyZAP-70 Protein-Tyrosine Kinase