Humoral immune response to 10-valent pneumococcal conjugate vaccine (PCV10) in individuals with type 2 diabetes mellitus.

BACKGROUND

Pneumococcal infections pose a significant health problem in individuals with comorbid conditions such as Type 2 diabetes mellitus. Although pneumococcal vaccines are recommended in individuals with type 2 diabetes, there is a lack of data on the immunogenicity of pneumococcal vaccines in the type 2 diabetes population. This pilot study was therefore developed to determine if the humoral immune response to the 10-valent pneumococcal conjugate vaccine (PCV10) in those with and without type 2 diabetes is comparable.

METHODS

A total of 40 (24 with type 2 diabetes and 16 without type 2 diabetes) adults were immunized with PCV10. WHO reference ELISA and multiplexed opsonophagocytic killing assay (MOPA) were used to measure the concentration and functionality of serotype-specific IgG at baseline and 14 days, 1 month, and 8 months post-vaccination.

RESULTS

The geometric mean IgG concentrations and opsonic titers increased significantly in post-immunization (T1-14 days, T2-1 month, and T3-8 month) serum samples compared to baseline (T0) in individuals with and without type 2 diabetes. In both groups, the highest post-immunization IgG concentrations were measured for serotype 19F at T2. Individuals with type 2 diabetes showed significantly lower IgG concentrations and opsonic titers for serotype 19F and 9V post-immunization compared to age and sex-matched non-diabetes individuals. Serotype-specific IgG concentrations declined rapidly in those with type 2 diabetes at 8 months post-immunization. Obese diabetes individuals had lower IgG concentrations compared to non-Obese individuals with type 2 diabetes.

CONCLUSION

Individuals with type 2 diabetes demonstrated a significant protective humoral immune response to the 10-valent pneumococcal conjugate vaccine (PCV10); however, the response was comparatively less robust and declined faster in those with type 2 diabetes compared to age and sex-matched non-diabetes controls.