MedElevator
Войти в исследования Frontiers in microbiology · 2026
Panton-Valentine Leukocidin and concurrent respiratory viral infection as risk factors for fatal Staphylococcus aureus bacteremia.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Zhou Liting, Guo Shiqi, Zhang Ting, Bi Ruru, Han Qingzhen, Guo Qiang
Аннотация
BACKGROUND: Staphylococcus aureus bacteremia (SAB) carries significant mortality. We sought to define clinical and pathogen-specific risk factors to guide early intervention.
METHODS: We conducted a retrospective cohort study of all SAB cases at our institution (Jan 2021-Mar 2025), expanding from an initial analysis of four fatal cases. Patient profiles, clinical characteristics and microbiological features were analyzed. Independent risk factors for mortality were determined through multivariate logistic regression.
RESULTS: Among 40 patients, mortality was higher in the community-associated Staphylococcus aureus (CASA) group (38.5% vs. 14.3%). Analysis revealed Panton-Valentine Leukocidin (PVL)-positive, methicillin-susceptible ST22 strains caused fatal outcomes in patients co-infected with influenza A or SARS-CoV-2, accompanied by severe leukopenia. Multivariate analysis identified fever before admission, PVL-positive S. aureus with respiratory viral co-infection, and ST22 strain infection as independent mortality risk factors. In the CASA subgroup, diabetes and PVL with viral co-infection were significant predictors.
CONCLUSION: PVL-producing strains, especially ST22, are key mortality drivers in SAB, with effects amplified by respiratory viral co-infection. Early recognition of PVL/viral co-infection and comorbidity management are critical for improving outcomes.
METHODS: We conducted a retrospective cohort study of all SAB cases at our institution (Jan 2021-Mar 2025), expanding from an initial analysis of four fatal cases. Patient profiles, clinical characteristics and microbiological features were analyzed. Independent risk factors for mortality were determined through multivariate logistic regression.
RESULTS: Among 40 patients, mortality was higher in the community-associated Staphylococcus aureus (CASA) group (38.5% vs. 14.3%). Analysis revealed Panton-Valentine Leukocidin (PVL)-positive, methicillin-susceptible ST22 strains caused fatal outcomes in patients co-infected with influenza A or SARS-CoV-2, accompanied by severe leukopenia. Multivariate analysis identified fever before admission, PVL-positive S. aureus with respiratory viral co-infection, and ST22 strain infection as independent mortality risk factors. In the CASA subgroup, diabetes and PVL with viral co-infection were significant predictors.
CONCLUSION: PVL-producing strains, especially ST22, are key mortality drivers in SAB, with effects amplified by respiratory viral co-infection. Early recognition of PVL/viral co-infection and comorbidity management are critical for improving outcomes.