[Collodion baby with transition to mild lamellar ichthyosis.Clinical course, histopathology and ultrastructural findings].

The case of a collodion baby in whom the condition evolved into a mild form of lamellar ichthyosis is presented. The clinical course was impressive: the hard, collodion-like horny membrane started to crack soon after the birth and had detached completely at the 9th day of life; after a few more days, almost complete clearing of the skin had occurred. At the age of 10 months, the child had only a very mild lamellar ichthyosis. Whereas light microscopy revealed only compact hyperkeratosis on the 1st day of life, electron microscopy suggested a favourable prognosis even at this early stage, which has been corroborated by the ensuing clinical course.