Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke · 2025
Cystoscopic injection of botulinum toxin for urgency incontinence.
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Myhr Siv Svennevik, Schiøtz Hjalmar A
Аннотация
BACKGROUND: Urgency incontinence is a common condition that can be difficult to treat. Cystoscopic injection of botulinum toxin into the bladder wall is a treatment option when conservative treatment has failed. The aim of the study was to evaluate the treatment outcomes and clinical benefits of botulinum toxin injection.
MATERIAL AND METHOD: We performed a retrospective record-based study at the Department of Gynaecology, Vestfold Hospital, of women who received intravesical botulinum toxin for urgency incontinence in the period 2014 - 2022 after failing to respond to conservative treatment. The primary endpoint was treatment satisfaction. Secondary endpoints were self-reported continence, repeated injections, treatment interval and complications.
RESULTS: A total of 167 women received treatment, with 403 injections administered. At the outpatient follow-up six months post-injection, 297/391 (76 %) reported being satisfied with the treatment and 272/384 (71 %) reported having regained continence. One or more complications were recorded in 79 of 395 (20 %) injections: 48 urinary tract infections, 25 cases requiring catheterisation due to impaired bladder emptying, and 6 cases of pain.
INTERPRETATION: Cystoscopic injection of botulinum toxin may be useful when conservative treatment for urgency incontinence has not led to adequate improvement. However, the method is not without risk of complications.
MATERIAL AND METHOD: We performed a retrospective record-based study at the Department of Gynaecology, Vestfold Hospital, of women who received intravesical botulinum toxin for urgency incontinence in the period 2014 - 2022 after failing to respond to conservative treatment. The primary endpoint was treatment satisfaction. Secondary endpoints were self-reported continence, repeated injections, treatment interval and complications.
RESULTS: A total of 167 women received treatment, with 403 injections administered. At the outpatient follow-up six months post-injection, 297/391 (76 %) reported being satisfied with the treatment and 272/384 (71 %) reported having regained continence. One or more complications were recorded in 79 of 395 (20 %) injections: 48 urinary tract infections, 25 cases requiring catheterisation due to impaired bladder emptying, and 6 cases of pain.
INTERPRETATION: Cystoscopic injection of botulinum toxin may be useful when conservative treatment for urgency incontinence has not led to adequate improvement. However, the method is not without risk of complications.